MreB Perturbing Compound A22 (hydrochloride)
Product Specifications
UNSPSC Description
MreB Perturbing Compound A22 hydrochloride is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly. MreB Perturbing Compound A22 hydrochloride blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC=3.1 µg/ml).
Target Antigen
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mreb-perturbing-compound-a22-hydrochloride.html
Purity
99.3
Solubility
DMF : ≥ 20 mg/mL|DMSO : ≥ 20 mg/mL|Ethanol : ≥ 1 mg/mL
Smiles
ClC1=CC(CSC(N)=N)=CC=C1Cl.Cl
Molecular Weight
271.59
References & Citations
[1]Zemer Gitai, et al. MreB actin-mediated segregation of a specific region of a bacterial chromosome. Cell. 2005 Feb 11;120(3):329-41.|[2]Noritaka Iwai, et al. Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein(s) other than penicillin-binding protein 2. Biosci Biotechnol Biochem. 2002 Dec;66(12):2658-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118773/MreB-Perturbing-Compound-A22-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118773/MreB-Perturbing-Compound-A22-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
22816-60-0
Available Sizes
Curated Selection
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