MreB Perturbing Compound A22 (hydrochloride)

MreB Perturbing Compound A22 hydrochloride is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly. MreB Perturbing Compound A22 hydrochloride blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC=3.1 µg/ml) .

Product Specifications

CAS Number

[22816-60-0]

Product Name Alternative

A22 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mreb-perturbing-compound-a22-hydrochloride.html

Purity

99.97

Solubility

DMF : ≥ 20 mg/mL|DMSO : ≥ 20 mg/mL|Ethanol : ≥ 1 mg/mL

Smiles

ClC1=CC(CSC(N)=N)=CC=C1Cl.Cl

Molecular Formula

C8H9Cl3N2S

Molecular Weight

271.59

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Zemer Gitai, et al. MreB actin-mediated segregation of a specific region of a bacterial chromosome. Cell. 2005 Feb 11;120 (3) :329-41.|[2]Noritaka Iwai, et al. Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein (s) other than penicillin-binding protein 2. Biosci Biotechnol Biochem. 2002 Dec;66 (12) :2658-62.