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(+) -LRH-1 modulator-1

(+) -LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1. LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 has anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces the anti-inflammatory cytokine IL-10 and reduces the inflammatory cytokines IL-1b and TNFa[1].

Product Specifications

UNSPSC

12352005

Target

Interleukin Related; Orphan Nuclear Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/plus-lrh-1-modulator-1.html

Purity

99.38

Smiles

C=C(C1=CC=CC=C1)[C@]([C@](C2)([H])[C@H]3N[S](N)(=O)=O)(CC3)C(C4=CC=CC=C4)=C2CCCCCC

Molecular Formula

C28H36N2O2S

Molecular Weight

464.66

References & Citations

[1]Mays S G, et al. Development of the first low nanomolar liver receptor homolog-1 agonist through structure-guided design[J]. Journal of medicinal chemistry, 2019, 62 (24) : 11022-11034.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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