ACT-373898

ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist[1].

Product Specifications

CAS Number

[1433875-14-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Endothelin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/act-373898.html

Solubility

10 mM in DMSO

Smiles

O=C(O)COC1=NC=NC(NS(=O)(NCCC)=O)=C1C2=CC=C(Br)C=C2

Molecular Formula

C15H17BrN4O5S

Molecular Weight

445.29

Precautions

P264-P270-P330-P501

References & Citations

[1]Shirin Bruderer, et al. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist. AAPS J. 2012 Mar;14 (1) :68-78.