HSD17B13-IN-14
HSD17B13-IN-14 (Compound 4) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 1 μM for leukotriene B3 and ≤ 0.1 μM for estradiol. HSD17B13-IN-14 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) [1].
Product Specifications
CAS Number
2758802-05-8
UNSPSC
12352005
Target
17β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hsd17b13-in-14.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(NC(C2=CC=C(O)C(Cl)=C2)=O)C=CS1)NCC3=CNC4=C3C=CC=C4
Molecular Formula
C21H16ClN3O3S
Molecular Weight
425.89
References & Citations
[1]Odingo J, et al. Thiophene hsd17b13 inhibitors and uses thereof. U.S., WO2022020714. 2023-09-07.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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