Dimethindene (maleate)

Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3].

Product Specifications

CAS Number

[3614-69-5]

UNSPSC

12352005

Hazard Statement

H302, H411

Target

Endogenous Metabolite; Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dimethindene-maleate.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3.O=C(O)/C=C\C(O)=O

Molecular Formula

C24H28N2O4

Molecular Weight

408.49

Precautions

H302, H411

References & Citations

[1]Weller K, et, al. Mast cells are required for normal healing of skin wounds in mice. FASEB J. 2006 Nov;20 (13) :2366-8.|[2]Sakuta H. Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266 (1) :99-102.|[3]Towart R, et al. Investigation of the antihistaminic action of dimethindene maleate (Fenistil) and its optical isomers. Agents Actions Suppl. 1991;33:403-8.