VEGF-IN-1

VEGF-IN-1 (compound 6) can reduce the release of VEGF in U87-MG cells and inhibit angiogenesis in vitro. VEGF-IN-1 can inhibit cell proliferation by inducing autophagy in tumor cells, with an IC50 value of 28.35 μM for U87-MG cells[1].

Product Specifications

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegf-in-1.html

Smiles

CC(C=C1)=CC=C1C2=NC3=C(N2)C4=C(C5=C3C=CC=[N]5[Ru]6([])Cl)[N]6=CC=C4.Cc7ccccc7.[Cl-]

Molecular Formula

C27H22Cl2N4Ru

Molecular Weight

574.47

References & Citations

[1]Yuan C, et al. Discovery of Arene Ruthenium (II) Complexes as Potential VEGF Inhibitors for Glioblastoma Metastasis Suppression. J Med Chem. 2024 Nov 14;67 (21) :18724-18740.