VEGF-IN-1
VEGF-IN-1 (compound 6) can reduce the release of VEGF in U87-MG cells and inhibit angiogenesis in vitro. VEGF-IN-1 can inhibit cell proliferation by inducing autophagy in tumor cells, with an IC50 value of 28.35 μM for U87-MG cells[1].
Product Specifications
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegf-in-1.html
Smiles
CC(C=C1)=CC=C1C2=NC3=C(N2)C4=C(C5=C3C=CC=[N]5[Ru]6([])Cl)[N]6=CC=C4.Cc7ccccc7.[Cl-]
Molecular Formula
C27H22Cl2N4Ru
Molecular Weight
574.47
References & Citations
[1]Yuan C, et al. Discovery of Arene Ruthenium (II) Complexes as Potential VEGF Inhibitors for Glioblastoma Metastasis Suppression. J Med Chem. 2024 Nov 14;67 (21) :18724-18740.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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