Coptisine
Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.
Product Specifications
CAS Number
3486-66-6
Product Name Alternative
Coptisin
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Coptisine.html
Solubility
10 mM in DMSO
Smiles
C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6
Molecular Formula
C19H14NO4
Molecular Weight
320.32
References & Citations
[1]Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43 (1) :291-302.|[2]He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50 (2) :185-94.|[3]Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39 (3) :1010428317694565.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IDO
Citation 01
DNA Cell Biol. 2020 Oct 2.|J Oncol. 2022 Jun 26:2022:9864411.|SSRN. 2024 Apr 1.|Int Immunopharmacol. 2024 Feb 15:128:111433.|Molecules. 2024 May 14.|Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398 (5) :5465-5474.|Phytomedicine. 2025 Oct 21:148:157446.|Planta Med. 2024 Jun;90 (7-08) :523-533.
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