Elexacaftor

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) . Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface[1].

Product Specifications

CAS Number

[2216712-66-0]

Product Name Alternative

VX-445

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; CFTR

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cftr-corrector-1.html

Purity

99.74

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2

Molecular Formula

C26H34F3N7O4S

Molecular Weight

597.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR , PHARMACEUTICAL COMPOSITIONS , METHODS OF TREATMENT , AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1.|[2]Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379 (17) :1612-1620.