Elexacaftor
Product Specifications
UNSPSC Description
Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface[1].
Target Antigen
Autophagy; CFTR
Type
Reference compound
Related Pathways
Autophagy;Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cftr-corrector-1.html
Purity
99.74
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2
Molecular Weight
597.65
References & Citations
[1]Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR , PHARMACEUTICAL COMPOSITIONS , METHODS OF TREATMENT , AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1.|[2]Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379(17):1612-1620.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111772/Elexacaftor-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111772/Elexacaftor-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
2216712-66-0
Available Sizes
Curated Selection
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