CARM1-IN-3 (dihydrochloride)

CARM1-IN-3 dihydrochloride (compound 17b) is a potent and selective co-activator associated arginine methyltransferase (CARM1) inhibitor with IC50 values of 0.07, >25 µM for CARM1 and CARM3, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carm1-in-3-dihydrochloride.html

Purity

98.77

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

CNCCN1CCC(C2=CC3=C(N=C(C4=C(OC)C=CC=C4OC)N3)C(C)=C2)CC1.Cl.Cl

Molecular Formula

C24H34Cl2N4O2

Molecular Weight

481.46

References & Citations

[1]Wan H, et al. Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1) --Hit to Lead studies. Bioorg Med Chem Lett. 2009 Sep 1;19 (17) :5063-6.