CARM1-IN-3 (dihydrochloride)
CARM1-IN-3 dihydrochloride (compound 17b) is a potent and selective co-activator associated arginine methyltransferase (CARM1) inhibitor with IC50 values of 0.07, >25 µM for CARM1 and CARM3, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/carm1-in-3-dihydrochloride.html
Purity
98.77
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
CNCCN1CCC(C2=CC3=C(N=C(C4=C(OC)C=CC=C4OC)N3)C(C)=C2)CC1.Cl.Cl
Molecular Formula
C24H34Cl2N4O2
Molecular Weight
481.46
References & Citations
[1]Wan H, et al. Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1) --Hit to Lead studies. Bioorg Med Chem Lett. 2009 Sep 1;19 (17) :5063-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT4
Available Sizes
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