Pyridoxal phosphate-d5
Product Specifications
UNSPSC Description
Pyridoxal phosphate-d5 is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia[1][2].
Target Antigen
Endogenous Metabolite; Isotope-Labeled Compounds; Reverse Transcriptase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Metabolic Enzyme/Protease;Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.30
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
C(OP(=O)(O)O)(C=1C(C=O)=C(O)C(C([2H])([2H])[2H])=NC1)([2H])[2H]
Molecular Weight
252.17
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7.|[3]Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Clinical Information
No Development Reported
CAS Number
1246818-16-5
Curated Selection
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