Pyridoxal phosphate-d5

Pyridoxal phosphate-d5 is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia[1][2].

Product Specifications

CAS Number

[1246818-16-5]

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Reverse Transcriptase

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.30

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

C(OP(=O)(O)O)(C=1C(C=O)=C(O)C(C([2H])([2H])[2H])=NC1)([2H])[2H]

Molecular Formula

C8H5D5NO6P

Molecular Weight

252.17

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71 (1) :180-7.|[3]Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394 (1) :100-5.