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Rabbit anti Human SPT16 (Intermediate Domain)

Product Specifications

Background

SPT16 and SSRP1 are found in all eurkaryotic cells and exists as part of an essential heterodimer complex. Together, SPT16 and SSRP1 are a highly abundant nuclear complex that in mammals has been called FACT, or Facilitates Chromatin Transcription. FACT enhances the processivity of RNA polymerase II through nucleosomes. Evidence also points to a role for FACT in replication, possibly by enhancing DNA polymerase through nucleosomes as well.

CAS Number

9007-83-4

Synonyms

SSRP1

UniProt

Q9Y5B9

Host

Rabbit

Species Reactivity

Human,Mouse

Isotype

IgG

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

WB, IP

Field of Research

Signal Transduction

Purification Method

Ammonium Sulfate Precipitation

Assay Principle

Antibody can be used for Western blotting (5-10 µg/mL) and immunoprecipitation. Optimal concentration should be evaluated by serial dilutions.

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

Provided as solution in phosphate buffered saline with 0,08% sodium azide

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

References & Citations

1. Keller, D.M., et al. 'A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSPT16 and SSRP1.' Mol. Cell Biol. 2001, 7, 283-292

Shipping Conditions

Ambient Temperature, freeze upon arrival

Storage Conditions

Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

Functional Analysis

WB

Frequently Asked Questions

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