What is the catalog number for DPN?

The catalog number for DPN is HY-12452.

What sizes are available for DPN?

DPN is available in the following size(s): 5 mg, 10 mg, 10 mM - 1 mL, 50 mg, 100 mg, 500 mg.

How many pack sizes does DPN come in?

DPN is available in 6 different pack sizes.

DPN is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DPN?

DPN is manufactured by QuantiMol.

What is the estimated delivery time for DPN?

Estimated delivery time for DPN is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DPN?

The safety data sheet for DPN is available here: http://file.medchemexpress.com/batch_PDF/HY-12452/DPN-SDS-MedChemExpress.pdf.

DPN

DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases[1][2].

Product Specifications

CAS Number

1428-67-7

Product Name Alternative

Diarylpropionitrile

UNSPSC

12352005

Hazard Statement

H319, H400

Target

Apoptosis; Autophagy; Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/DPN.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(CC(C#N)C2=CC=C(O)C=C2)C=C1

Molecular Formula

C15H13NO2

Molecular Weight

239.27

Precautions

H319, H400

References & Citations

[1]Suwanna N, et al. Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neurosci Lett. 2014 Aug 22;578:44-9.|[2]Meyers, M. J., et al. Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues. Journal of Medicinal Chemistry, 2001. 44 (24), 4230–4251.|[3]Fuzhong Yang, et al. Physiological dosages of estradiol and diarylpropionitrile decrease depressive behavior and increase tryptophan hydroxylase expression in the dorsal raphe nucleus of rats subjected to the forced swim test. Neuroreport. 2019 Jan 16;30 (2) :66-70.|[4]Sherry A. Said, et al. Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice. GeroScience. 2018 Aug; 40 (4) : 393–403.