Begacestat

Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease[1].

Product Specifications

CAS Number

[769169-27-9]

Product Name Alternative

GSI-953

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Begacestat.html

Concentration

10mM

Purity

99.29

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC(F)(F)C([C@H](NS(=O)(C1=CC=C(Cl)S1)=O)CO)C(F)(F)F

Molecular Formula

C9H8ClF6NO3S2

Molecular Weight

391.74

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Mayer SC, et al. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. J Med Chem. 2008 Dec 11;51 (23) :7348-51.|[2]Martone RL, et al. Begacestat (GSI-953) : a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther. 2009 Nov;331 (2) :598-608.