6,8-Diprenylnaringenin
Product Specifications
Product Name Alternative
Lonchocarpol A; Senegalensin
UNSPSC Description
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].
Target Antigen
BCRP
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/6-8-diprenylnaringenin.html
Solubility
10 mM in DMSO
Smiles
O=C1C[C@H](OC2=C(C(O)=C(C(O)=C12)C/C=C(C)\C)C/C=C(C)\C)C3=CC=C(C=C3)O
Molecular Weight
408.49
References & Citations
[1]Milligan SR, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. 2000 Dec;85(12):4912-5. |[2]Tan KW, et al. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol Nutr Food Res. 2014 Nov;58(11):2099-110.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122416/6-8-Diprenylnaringenin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122416/
Clinical Information
No Development Reported
CAS Number
68236-11-3
Available Sizes
Curated Selection
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