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5-Azacytidine-15N4

5-Azacytidine-15N4 is 13C and 15N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy[1][2][3][4].

Product Specifications

CAS Number

2139283-40-0

Product Name Alternative

Azacitidine-15N4; 5-AzaC-15N4; Ladakamycin-15N4

UNSPSC

12352005

Target

Antibiotic; Autophagy; Bacterial; DNA Methyltransferase; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog; Organoid

Type

Reference compound

Related Pathways

Anti-infection; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others; Stem Cell/Wnt

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/5-azacytidine-15n4.html

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H]([15N](C=[15N]2)C([15N]=C2[15NH2])=O)O1

Molecular Formula

C8H12 15N4O5

Molecular Weight

248.18

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Li LH, et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov;30 (11) :2760-9.|[3]Christman JK. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21 (35) :5483-95.|[4]Creusot F, et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2'-deoxycytidine. J Biol Chem. 1982 Feb 25;257 (4) :2041-8.|[5]Marycz K, et al. 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.Oxid Med Cell Longev. 2019 May 12;2019:1523140.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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