DA-143

Product Specifications

UNSPSC Description

DA-143 is a selective DNA-PKcs inhibitor (IC50: 2.5 nM), and the IC50s for mTOR, PI3KΔ, and ATM are 280 nM, 106 nM and 6,594 nM respectively. DA-143 blocks phosphorylation of DNA-PKcs substrates. DA-143 sensitizes cancer cells to Doxorubicin (HY-15142)[1].

Target Antigen

mTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/da-143.html

Smiles

O=C1C=C(OC2=C1C=CC=C2C3=C4SC5=CC=C(C=C5C4=CC=C3)C6=CN(N=C6)CCN7CCCC7)N8CCOCC8

Molecular Weight

576.71

References & Citations

[1]Waldrip ZJ, et al. Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441. Sci Rep. 2024 Aug 28;14(1):19999.