ST2-IN-1
ST2-IN-1 (compound 31) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 7 μM in AlphaLISA assay, and 7.19 μM in HEK-Blue assay. ST2-IN-1 effectively attenuats the ST2/IL-33 signaling in human mast cells[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/st2-in-1.html
Concentration
10mM
Purity
99.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C1=CC=C(C=C1)C2CCCN2CC3=CC=C(N3)C4=CC=C(C(N5CCCC5)=C4)[N+]([O-])=O)C
Molecular Formula
C27H33N5O2
Molecular Weight
459.58
References & Citations
[1]Xinrui Yuan, et al. Studies of Structure–Activity Relationship of 2- (Pyrrolidin-1ylmethyl) -1H-pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation. ACS Med. Chem. Lett. October 18, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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