Nrf2 activator-11

Nrf2 activator-11 (compound M11) is a Nrf2 activator with blood-brain permeability. Nrf2 activator-11 has anti-oxidation, anti-inflammation, anti-ferroptosis and anti-apoptosis. Nrf2 activator-11 can be used to study cerebral ischemia-reperfusion (CI/R) injury models[1].

Product Specifications

CAS Number

[3069351-39-6]

UNSPSC

12352005

Target

Apoptosis; Keap1-Nrf2

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nrf2-activator-11.html

Smiles

O=C(C1=C(O)C=C(C)C=C1)NCCC2=CNC3=CC=C(N(C)C)C=C32

Molecular Formula

C20H23N3O2

Molecular Weight

337.42

References & Citations

[1]Wu G, et al. Design, synthesis and biological evaluation of N-salicyloyl tryptamine derivatives as multifunctional neuroprotectants for the treatment of ischemic stroke. Eur J Med Chem. 2024 Nov 15;278:116795.