TRAP-1
TRAP-1 (XJZ-06-462) is a selective p53Y220C transcriptional activator. TRAP-1 can engage p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 exhibits higher antiproliferative activity in BxPC-3 (p53Y220C) cells than in A549 cells (p53WT), with IC50 values of 0.531 μM and 3.94 μM, respectively. TRAP-1 can be used for the study of p53Y220C-bearing cancer.
Product Specifications
Product Name Alternative
XJZ-06-462
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trap-1.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C57H66ClF3N11O3PS
Molecular Weight
1108.69
References & Citations
[1]Xijun Zhu, et al. Activating p53Y220C with a Mutant-Specific Small Molecule. bioRxiv. 2024 Oct 28:2024.10.23.619961.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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