Chlorothymol

Chlothymol is a potent positive modulator of the GABAA receptor subunit LGC-37, anticonvulsant, and antibacterial agent. Chlothymol inhibits Pentylenetetrazol-induced c-fos expression. Chlothymol inhibits the growth of Methicillin (HY-121544) -resistant Staphylococcus aureus (MRSA) strains, including LAC, with an MIC of 32 μg/mL. Chlorothymol has protective effects against epileptic seizures in various mouse models[1][2].

Product Specifications

CAS Number

[89-68-9]

Product Name Alternative

Chlorthymol; 6-Chlorothymol

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

AP-1; Bacterial; GABA Receptor

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chlorothymol.html

Purity

99.70

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C1=C(O)C=C(C)C(Cl)=C1)C

Molecular Formula

C10H13ClO

Molecular Weight

184.67

Precautions

H315, H319, H335

References & Citations

[1]Alistair Jones, et al. A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant. Epilepsia. 2020 Oct;61 (10) :2106-2118. |[2]Kim BC, et al. 4-Chloro-2-Isopropyl-5-Methylphenol Exhibits Antimicrobial and Adjuvant Activity against Methicillin-Resistant Staphylococcus aureus. J Microbiol Biotechnol. 2022 Jun 28;32 (6) :730-739.