ICI 169369

ICI 169369 is an orally active, specific serotonin and 5-HT2/5-HT1C receptor competitive antagonist. ICI 169369 exhibits Ki values of 1.79 x 10−8 and 1.58 x 10−6 M for 5-HT2 and 5-HT1, respectively[1][2].

Product Specifications

CAS Number

[85273-96-7]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ici-169369.html

Smiles

CN(C)CCSC1=NC2=CC=CC=C2C=C1C3=CC=CC=C3.Cl

Molecular Formula

C19H21ClN2S

Molecular Weight

344.90

References & Citations

[1]D S Millson, et al. The effects of a 5-HT2 receptor antagonist (ICI 169,369) on changes in waking EEG, pupillary responses and state of arousal in human volunteers. Br J Clin Pharmacol. 1991 Oct;32 (4) :447-54.|[2]T P Blackburn, et al. In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist. Eur J Pharmacol. 1988 Jun 10;150 (3) :247-56.