Triiodothyronine sulfate
Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3) . Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity[1][2].
Product Specifications
CAS Number
31135-55-4
UNSPSC
12352005
Target
Drug Metabolite; Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/triiodothyronine-sulfate.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
N[C@@H](CC1=CC(I)=C(OC2=CC=C(OS(=O)(O)=O)C(I)=C2)C(I)=C1)C(O)=O
Molecular Formula
C15H12I3NO7S
Molecular Weight
731.04
References & Citations
[1]J S LoPresti, et al. 3,5,3'-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in man. J Clin Endocrinol Metab. 1994 Mar;78 (3) :688-92.|[2]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85 (2) :189-94.|[3]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195 (1) :385-92.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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