Cinitapride

Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research[1].

Product Specifications

CAS Number

[66564-14-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cinitapride.html

Purity

98.24

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1CCN(CC2CC=CCC2)CC1)C3=CC([N+]([O-])=O)=C(N)C=C3OCC

Molecular Formula

C21H30N4O4

Molecular Weight

402.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Du Y, et al. Efficacy and safety of cinitapride in the treatment of mild to moderate postprandial distress syndrome-predominant functional dyspepsia. J Clin Gastroenterol. 2014 Apr;48 (4) :328-35.|[2]Alarcón de la Lastra C, et al. Effects of cinitapride on gastric ulceration and secretion in rats. Inflamm Res. 1998 Mar;47 (3) :131-6.|[3]Alarcón-de-la-Lastra Romero C, et al. Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds. Pharmacology. 1997 Apr;54 (4) :193-202.