S1QEL1.1
S1QEL1.1 is a small molecule inhibitor that specifically inhibits the generation of superoxide and hydrogen peroxide at the IQ site during reverse electron transfer in mitochondrial respiratory chain complex I (Complex I), with an IC50 of 0.07 μM. S1QEL1.1 can significantly reduce the activation of cysteine-aspartic protease (caspase) triggered by endoplasmic reticulum stress. S1QEL1.1 helps to decrease excessive proliferation of stem cells by inhibiting the Reactive Oxygen Species signaling pathway initiated by endoplasmic reticulum stress[1].
Product Specifications
CAS Number
[897613-29-5]
UNSPSC
12352005
Hazard Statement
H302, H372, H411
Target
Caspase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/s1qel1-1.html
Purity
99.9
Smiles
O=C(NC1=CC=CC(NC(C)=O)=C1)C(NCCC2=C(C)N=C(C3=CC=C(C)C=C3)S2)=O
Molecular Formula
C23H24N4O3S
Molecular Weight
436.53
Precautions
H302, H372, H411
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4, BP-4, HT29-IGFBP, IBP4)
ATM (Serine-protein Kinase ATM, Ataxia Telangiectasia Mutated, A-T Mutated) (AP)
ATM (Serine-protein Kinase ATM, Ataxia Telangiectasia Mutated, A-T Mutated) (AP)