S1QEL1.1

S1QEL1.1 is a small molecule inhibitor that specifically inhibits the generation of superoxide and hydrogen peroxide at the IQ site during reverse electron transfer in mitochondrial respiratory chain complex I (Complex I), with an IC50 of 0.07 μM. S1QEL1.1 can significantly reduce the activation of cysteine-aspartic protease (caspase) triggered by endoplasmic reticulum stress. S1QEL1.1 helps to decrease excessive proliferation of stem cells by inhibiting the Reactive Oxygen Species signaling pathway initiated by endoplasmic reticulum stress[1].

Product Specifications

CAS Number

[897613-29-5]

UNSPSC

12352005

Hazard Statement

H302, H372, H411

Target

Caspase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/s1qel1-1.html

Purity

99.9

Smiles

O=C(NC1=CC=CC(NC(C)=O)=C1)C(NCCC2=C(C)N=C(C3=CC=C(C)C=C3)S2)=O

Molecular Formula

C23H24N4O3S

Molecular Weight

436.53

Precautions

H302, H372, H411

References & Citations

[1]Martin D Brand, et al. Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metab. 2016 Oct 11;24 (4) :582-592.