Aurein 2.2

Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an antibiotic with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis[1][2].

Product Specifications

CAS Number

[302343-04-0]

UNSPSC

12352209

Target

Antibiotic; Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/aurein-2-2.html

Solubility

10 mM in DMSO

Smiles

CC(C)C[C@@H](C(N)=O)NC([C@H](CO)NC(CNC([C@H](CC(C)C)NC([C@H](C)NC(CNC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CC(C)C)NC(CN)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C76H131N19O19

Molecular Weight

1614.97

References & Citations

[1]Rozek T, et al. The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. Eur J Biochem. 2000 Sep;267 (17) :5330-41.|[2]Raheem N, et al. Insights into the mechanism of action of two analogues of aurein 2.2. Biochim Biophys Acta Biomembr. 2020 Jun 1;1862 (6) :183262.