Vc-seco-DUBA
Vc-seco-DUBA (Duocarmazine) is a agent-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco[1].
Product Specifications
CAS Number
[1345681-58-4]
Product Name Alternative
Duocarmazine
UNSPSC
12352203
Hazard Statement
H340-H351-H373
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/modified-mc-vc-pabc.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCCOCCN2C(C=CC2=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C1)N(C)CCN(C(OC3=CC(N(C[C@H]4CCl)C(C5=CN6C=C(C=CC6=N5)NC(C(C=C7)=CC=C7O)=O)=O)=C4C8=C(C)C=CC=C83)=O)CCOCCO
Molecular Formula
C65H75ClN12O17
Molecular Weight
1331.81
Precautions
P260-P280-P405-P501
References & Citations
[1]Samantha Congreve, et al. Antibody drug conjugates (ADC) Current status and mapping of ADC:s in clinical programs.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
ADC Related
Clinical Information
Phase 2
Isoform
Duocarmycins
Available Sizes
Curated Selection
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