Ferutinin

Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities[1][2].

Product Specifications

CAS Number

[41743-44-6]

UNSPSC

12352005

Target

Apoptosis; Estrogen Receptor/ERR

Type

Natural Products

Related Pathways

Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ferutinin.html

Purity

99.23

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O[C@@H]1[C@@]2([H])[C@@](C(C)C)(O)CC[C@]2(C)CC=C(C)C1)C3=CC=C(O)C=C3

Molecular Formula

C22H30O4

Molecular Weight

358.47

References & Citations

[1]Kazuhiro Ikeda, et al. Terpenoids found in the umbelliferae family act as agonists/antagonists for ER (alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER (alpha) and ERbeta. Biochem Biophys Res Commun. 2002 Feb 22;291 (2) :354-60. |[2]Tatsiana Ilyich, et al. Ferutinin Induces Membrane Depolarization, Permeability Transition Pore Formation, and Respiration Uncoupling in Isolated Rat Liver Mitochondria by Stimulation of Ca 2+-Permeability. J Membr Biol. 2018 Aug;251 (4) :563-572.