(-) -Domesticine
(-) -Domesticine is an anti-α-1D-adrenoceptor compound with cytotoxic activity. (-) -Domesticine showed activity in MTS cytotoxicity assays against human colon cancer cell lines HCT-116 and Caco-2. (-) -Domesticine tolerates alkoxy substituents and benzoate functional groups at the C1 position in modifications of its chemical structure. The most potent compounds of (-) -Domesticine have IC50 values in the range of 23-38 μM, similar to the known cytotoxic compound etoposide[1].
Product Specifications
CAS Number
[54325-07-4]
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minus-domesticine.html
Smiles
OC(C(OC)=C1)=C2C3=C1CCN(C)[C@]3([H])CC4=C2C=C5OCOC5=C4
Molecular Formula
C19H19NO4
Molecular Weight
325.36
References & Citations
[1]Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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