DHODH-IN-17

DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor (IC50=0.40 μM) . DHODH-IN-17 can be used for theresearch of acute myeloid leukemia (AML) [1].

Product Specifications

CAS Number

[16344-26-6]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dhodh-in-17.html

Purity

99.91

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CN=C1NC2=CC=C(Cl)C=C2)O

Molecular Formula

C12H9ClN2O2

Molecular Weight

248.67

References & Citations

[1]Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016;7 (12) :1112-1117.