DHODH-IN-17
DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor (IC50=0.40 μM) . DHODH-IN-17 can be used for theresearch of acute myeloid leukemia (AML) [1].
Product Specifications
CAS Number
[16344-26-6]
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhodh-in-17.html
Purity
99.91
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CN=C1NC2=CC=C(Cl)C=C2)O
Molecular Formula
C12H9ClN2O2
Molecular Weight
248.67
References & Citations
[1]Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016;7 (12) :1112-1117.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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