Benzamidine

Benzamidine is a reversible competitive trypsin inhibitor with a Ki of 19 μM[1]. Benzamidine shows inhibitory activity against homogeneous boar sperm acrosin with a Ki of 4 μM[2].

Product Specifications

CAS Number

[618-39-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/benzamidine.html

Purity

98.70

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N=C(C1=CC=CC=C1)N

Molecular Formula

C7H8N2

Molecular Weight

120.15

Precautions

H302, H315, H319, H335

References & Citations

[1]R F Parrish, et al. Structure-activity relationships for the inhibition of acrosin by benzamidine derivatives. J Med Chem. 1978 Nov;21 (11) :1132-6. |[2]K Tanizawa, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69 (5) :893-9.