PFI-653

PFI-653 (Vanin-1-IN-1, compound 3), a chemical probe, is a vanin-1 inhibitor that binds to plasma vanin-1 from mouse, rat, dog, and human. Vanin-1 is a cell surface-associated inositol (GPi) -anchored protein that plays important roles in metabolism and inflammation. PFI-653 inhibits vanin-1 from different species with IC50s of 6.85 nM (human recombinant plasma vanin-1), 9.0 nM (human plasma vanin-1), 24.5 nM (mouse recombinant vanin-1), and 53.4 nM (mouse plasma vanin-1) [1][2].

Product Specifications

CAS Number

2173134-00-2

Product Name Alternative

Vanin-1-IN-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Pantetheinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pfi-653.html

Purity

99.92

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1CC2(CCOCC2)CC1)C3=CN=C(NCC4=NC=CN=C4)N=C3

Molecular Formula

C18H22N6O2

Molecular Weight

354.41

Precautions

H302, H315, H319

References & Citations

[1]Casimiro-Garcia A, et al. Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem. 2022 Jan 13;65 (1) :757-784.|[2]Agustin Casimiro-Garcia, et al. Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme. WO2018011681A1.