Chondroitinase ABC

Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) core protein. Chondroitinase ABC facilitates reinnervation by degrading CS-GAGs around motoneurons. Chondroitinase ABC has the potential for the research of spinal injury[1][2].

Product Specifications

CAS Number

[9024-13-9]

Product Name Alternative

ChABC

UNSPSC

12352204

Target

Endogenous Metabolite

Type

Enzyme

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chondroitinase-abc.html

Solubility

10 mM in DMSO

Smiles

[ChondroitinaseABC]

References & Citations

[1]Mahajan R, et al. Chondroitinase ABC Enzyme: A Potential Treatment Option for Spinal Cord Injury. Int J Appl Basic Med Res. 2018 Oct-Dec;8 (4) :203.|[2]Takiguchi M, et al. Chondroitinase ABC Administration Facilitates Serotonergic Innervation of Motoneurons in Rats With Complete Spinal Cord Transection. Front Integr Neurosci. 2022 Jun 30;16:881632.