KRAS G12D-IN-31
KRAS G12D-IN-31 is a potent KRAS G12D inhibitor with an IC50 of G12C, KRAS G12D, KRASG12V and KRASWT) . KRAS G12D-IN-31 can be used to study non-small cell lung cancer, gastric cancer, colon cancer, and malignant melanoma[1].
Product Specifications
CAS Number
[3024060-23-6]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-ras-in-4.html
Purity
98.53
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC(C=CC(F)=C2CC)=C2C(N3CC4=NC(OC[C@@]56N(CCC6)C[C@@H](C5)F)=NC(N7CC8=C9C(C(N(CC9)C)=O)=NN8CCC7)=C4CC3)=C1
Molecular Formula
C38H44F2N8O3
Molecular Weight
698.80
References & Citations
[1]ZSH Xu, et al. Nitrogen-containing polycyclic compound, and pharmaceutical composition and use thereof. WO2024067575A1
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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