KRAS G12D-IN-31

KRAS G12D-IN-31 is a potent KRAS G12D inhibitor with an IC50 of G12C, KRAS G12D, KRASG12V and KRASWT) . KRAS G12D-IN-31 can be used to study non-small cell lung cancer, gastric cancer, colon cancer, and malignant melanoma[1].

Product Specifications

CAS Number

[3024060-23-6]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pan-ras-in-4.html

Purity

98.53

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC(C=CC(F)=C2CC)=C2C(N3CC4=NC(OC[C@@]56N(CCC6)C[C@@H](C5)F)=NC(N7CC8=C9C(C(N(CC9)C)=O)=NN8CCC7)=C4CC3)=C1

Molecular Formula

C38H44F2N8O3

Molecular Weight

698.80

References & Citations

[1]ZSH Xu, et al. Nitrogen-containing polycyclic compound, and pharmaceutical composition and use thereof. WO2024067575A1

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

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