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SBI-810

SBI-810 is a functionally selected β-arrestin-biased neurotensin receptor 1 (NTSR1) allosteric modulator. SBI-810 modulates NTSR1 G protein signaling in a G protein-specific manner in the presence of the endogenous ligand, neurotensin (NT) . SBI-810 fully antagonizes NT-induced activation of Gq, partially antagonizes NT-induced activation of Gi1 and is permissive of NTSR1 activation of GoA and G12[1][2].

Product Specifications

CAS Number

1849603-79-7

UNSPSC

12352005

Target

Neurotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sbi-810.html

Purity

98.25

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OCCN(C)C1=CC2=C(N=C(C3(CC3)C)N=C2N4CCC(CC4)C5=C(OC)C=CC=C5)C=C1

Molecular Formula

C27H34N4O2

Molecular Weight

446.58

References & Citations

[1]Lawrence Barak, et al. Compositions for and methods of treating and/or preventing pain. WO2022241186A1. 2022 November 17.|[2]Center M N A, et al. Summer Undergraduate Research Expo[J]. 2014.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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