MSDC 0160

MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT) -modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC) . MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease[1][2].

Product Specifications

CAS Number

[146062-49-9]

Product Name Alternative

Mitoglitazone; CAY10415

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Insulin Receptor; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/MSDC_0160.html

Purity

99.37

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N1)SC(CC2=CC=C(OCC(C3=NC=C(CC)C=C3)=O)C=C2)C1=O

Molecular Formula

C19H18N2O4S

Molecular Weight

370.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Rohatgi N, et al. Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. PLoS One. 2013 May 1;8 (5) :e62012.|[2]Ghosh A, et al. Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration inexperimental models of Parkinson's disease. Sci Transl Med. 2016 Dec 7;8 (368) :368ra174.