CK-548
CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC50 of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection[1][2].
Product Specifications
CAS Number
[388604-55-5]
Product Name Alternative
CK-0993548
UNSPSC
12352005
Hazard Statement
H302, H400
Target
Arp2/3 Complex; HIV
Type
Reference compound
Related Pathways
Anti-infection; Cytoskeleton
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ck-548.html
Purity
90
Smiles
O=C1N(C(SC1)C2=CC=CC(Br)=C2)C3=CC(Cl)=CC=C3O
Molecular Formula
C15H11BrClNO2S
Molecular Weight
384.68
Precautions
H302, H400
References & Citations
[1]B. J. Nolen, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature.|[2]Spear M, et al. HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J Biol Chem. 2014;289 (10) :6949-6959.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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