α-Conotoxin AuIB
Product Specifications
UNSPSC Description
α-Conotoxin AuIB, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM[1].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
H2O
Smiles
O=C(CN)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N2[C@H]3CCC2)=O)CCC1)=O)CC4=CC=C(O)C=C4)=O)CO)=O)CSSC[C@H](NC5=O)C(N)=O)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H]5CC(O)=O)=O)CCC6)=O)CC(N)=O)=O)[C@@H](C)O)=O)C)=O)CC7=CC=CC=C7)=O
Molecular Weight
1572.76
References & Citations
[1]Siqin Luo, et al. α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release.Journal of Neuroscience. 1998 Nov 1, 18 (21): 8571-8579.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
216299-21-7
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