CCR2 antagonist 1
CCR2 antagonist 1 (compound 15a) is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM[1].
Product Specifications
CAS Number
[1683534-96-4]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/CCR2_antagonist_1.html
Purity
98.00
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C([C@]1(C(C)C)C[C@H](N[C@@H]2CCC3=C2C=CC(Br)=C3)CC1)N4CC5=C(C=CC(C(F)(F)F)=C5)CC4
Molecular Formula
C28H32BrF3N2O
Molecular Weight
549.47
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3- ((Inden-1-yl) amino) -1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR2
Available Sizes
Curated Selection
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