Apoptosis inducer 26

Apoptosis inducer 26 (compound [AgCl (dap2SH) (PPh3) 2]) is an autophagy inducer based on mononuclear Ag (I) ligands, with antibacterial and anticancer activities against a variety of bacterial strains and cancer cell lines. Apoptosis inducer 26 can effectively inhibit the growth of both Gram (+) and Gram (-) bacteria by causing the accumulation of Ag (I) ions in the bacterial periplasm. Apoptosis inducer 26 can intercalate between base pairs of CT DNA and induce apoptosis in A549 cells. Apoptosis inducer 26 also has the ability to scavenge free radicals, which can protect against oxidative stress[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apoptosis-inducer-26.html

Smiles

NC1=NC(NC(N)=C1)=[S][Ag]([P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)([P](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)Cl

Molecular Formula

C40H36AgClN4P2S

Molecular Weight

810.07

References & Citations

[1]Amine-substituted heterocyclic thioamide Cu (I) and Ag (I) complexes as effective anticancer and antibacterial agents targeting the periplasm of E. coli bacteria