A 438079 (hydrochloride)
A 438079 (hydrochloride) is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
Product Specifications
CAS Number
[899431-18-6]
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/A-438079-hydrochloride.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
ClC1=C(Cl)C(C2=NN=NN2CC3=CC=CN=C3)=CC=C1.[H]Cl
Molecular Formula
C13H10Cl3N5
Molecular Weight
342.61
Precautions
H228, H315, H319
References & Citations
[1]McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146 (4) :1817-28.|[2]Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20 (6) :556-64.|[3]Marcellino D, et al. On the role of P2X (7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X (7) receptor antagonist A-438079. J Neural Transm (Vienna) . 2010 Jun;117 (6) :681-7.|[4]Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165 (1) :183-96.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X7 Receptor
Citation 01
Basic Res Cardiol. 2025 Sep 16.|Cancer Immunol Res. 2020 Nov;8 (11) :1426-1439.|J Ethnopharmacol. 2024 Sep 7:118792.|J Immunol. 2023 Jun 15;210 (12) :1962-1973.|bioRxiv. 2025 May 8:2025.05.03.652022.|bioRxiv. 2025 Nov 19.|Brain, Behavior, and Immunity. 2020 Aug;88:507-514.|Eur J Pharmacol. 2025 May 15:995:177421.|Front Mol Neurosci. 2018 Nov 6;11:401.|Gen Physiol Biophys. 2019 Sep;38 (5) :407-416.|Inflammation. 2025 Jun 30.|Inflammation. 2025 Jun;48 (3) :987-1002.|Int J Mol Sci. 2022 May 17;23 (10) :5586.|J Adv Res. 2024 Jul 15:S2090-1232 (24) 00298-4.|J Agric Food Chem. 2025 Aug 27;73 (34) :21296-21308.|J Nanobiotechnology. 2025 May 5;23 (1) :332.|Med Oncol. 2025 Jul 16;42 (8) :340.|Med Sci Monit. 2020 Sep 21:26:e925491.|Neural Regen Res. 2021 Aug;16 (8) :1582-1591.|Purinergic Signal. 2023 Dec;19 (4) :685-697.|Purinergic Signal. 2024 Nov 16.
Available Sizes
Curated Selection
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