Tamsulosin

Tamsulosin ((R) - (-) -YM12617 free base) is an orally active antagonist of α1-adrenergic receptor. Tamsulosin induces Apoptosis. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[106133-20-4]

Product Name Alternative

(R) - (-) -YM12617 (free base) ; LY253351 (free base)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tamsulosin.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC(C[C@H](NCCOC2=CC=CC=C2OCC)C)=CC=C1OC)(N)=O

Molecular Formula

C20H28N2O5S

Molecular Weight

408.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Christopher Chapple, et al. Tamsulosin: an overview. World J Urol. 2002 Apr;19 (6) :397-404.|[2]Rak A, et al. Arylsulfonamide derivatives of (aryloxy) ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity. Bioorg Med Chem. 2016 Nov 1;24 (21) :5582-5591. |[3]Sun L, et al. Tamsulosin attenuates high glucose- induced injury in glomerular endothelial cells. Bioengineered. 2021 Dec;12 (1) :5184-5194.|[4]Ida Y, et al. The Selective α1 Antagonist Tamsulosin Alters ECM Distributions and Cellular Metabolic Functions of ARPE 19 Cells in a Concentration-Dependent Manner. Bioengineering (Basel) . 2022 Oct 14;9 (10) :556.|[5]Youm Y H, et al. Apoptosis Induction and Clusterin Expression of NRP-152 Cells by Tamsulosin. Journal of the Korean Continence Society, 2006, 10 (2) : 132-139.|[6]Kim SE, et al. Effects of Tamsulosin on Urinary Bladder Function and Neuronal Activity in the Voiding Centers of Rats with Cyclophosphamide-induced Overactive Bladder. Int Neurourol J. 2012 Mar;16 (1) :13-22.|[7]Alabdali H H, et al. Study the anti-inflammatory effects of tamsulosin by the evaluation of inflammatory cells and lung histopathology in an airway inflammation model in rats. Bulletin of Pharmaceutical Sciences. Assiut, 2023, 46 (1) : 633-645. |[8]Holanda VAD, et al. Tamsulosin facilitates depressive-like behaviors in mice: Involvement of endogenous glucocorticoids. Brain Res Bull. 2022 Jan;178:29-36.