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SIRT1-IN-2

SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM[1].

Product Specifications

CAS Number

2470969-89-0

UNSPSC

12352005

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sirt1-in-2.html

Concentration

10mM

Purity

98.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=C(NC2=CC=C(C=C21)Cl)CC(N)=O)C

Molecular Formula

C13H15ClN2O

Molecular Weight

250.72

References & Citations

[1]Laaroussi H, Ding Y, Teng Y, et al. Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents. Eur J Med Chem. 2020;202:112561.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT1; SIRT2

Available Sizes

Frequently Asked Questions

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