ZLY06
ZLY06 is an orally active dual agonist of peroxisome proliferator-activated receptor (PPAR) δ and γ (PPAR δ: EC50=341 nM; PPAR γ: EC50=237 nM) . ZLY06 induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1, mediating the upregulation of CD36. In addition, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, and alleviates fatty liver by promoting β-oxidation of fatty acids and inhibiting hepatic lipogenesis[1][2].
Product Specifications
CAS Number
2834727-04-5
UNSPSC
12352005
Target
Akt; PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/zly06.html
Concentration
10mM
Purity
98.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(/C=C2OC(C=C(OCC3CC3)C=C4)=C4C\2=O)=CC(C)=C1OC(C)(C)C(O)=O
Molecular Formula
C25H26O6
Molecular Weight
422.47
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ; PPARδ
Available Sizes
Frequently Asked Questions
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