Tilfrinib

Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour[1][2].

Product Specifications

CAS Number

[1600515-49-8]

UNSPSC

12352005

Target

BRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tilfrinib.html

Purity

99.39

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=CC(NC2=C3C4=CC=CC=C4NC3=NC=C2)=C1

Molecular Formula

C17H13N3O

Molecular Weight

275.30

References & Citations

[1]Mahmoud KA, et al. Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg Med Chem Lett. 2014 Apr 15;24 (8) :1948-51.|[2]Zhang Q, Liu S, et al. ETV4 mediated tumor-associated neutrophil recruitment promotes lymphangiogenesis and lymphatic metastasis of bladder cancer[J]. 2022.