Tilfrinib
Product Specifications
UNSPSC Description
Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour[1][2].
Target Antigen
BRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tilfrinib.html
Purity
99.69
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=CC=CC(NC2=C3C4=CC=CC=C4NC3=NC=C2)=C1
Molecular Weight
275.30
References & Citations
[1]Mahmoud KA, et al. Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1948-51.|[2]Zhang Q, Liu S, et al. ETV4 mediated tumor-associated neutrophil recruitment promotes lymphangiogenesis and lymphatic metastasis of bladder cancer[J]. 2022.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-110244/Tilfrinib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-110244/Tilfrinib-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1600515-49-8
Available Sizes
Curated Selection
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